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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. From ethical and scientific validity standpoints, in addition to double blinding, which of the following research designs is best for determining a new medication's relative efficacy in treating acute stroke?

A) Crossover design comparing the new therapy with the best standard therapy
B) Parallel design comparing the new therapy with the best standard therapy
C) Placebo-controlled, randomized, parallel design
D) Placebo-controlled, crossover design

2. A 50-year-old patient is admitted for acute coronary syndrome with a past medical history of hyperlipidemia and diabetes. The patient was transferred to the cardiac care unit for intubation because of worsening condition with increased shortness of breath. Physical examination and laboratory results reveal:
* BP: 140/90 mm Hg
* HR: 90 bpm
* RR:27 bpm
* O2 Sat: 90% on 2L
* Nasal cannula general: moderate distress
* Chest: bibasilar rales noted
* CV: S1, S2 present, + JVD 11 cm
* EXT. bilateral pulses, 2+ pitting edema, warm extremities
* BUN: 40 mg/dL
* Serum creatinine: 2.1 mg/dL
* Brain natriuretic peptide: 1120 pg/mL
Which of the following is the most appropriate first-line intravenous therapy for this patient?

A) Milrinone
B) Metolazone
C) Nitroprusside
D) Furosemide

3. A patient with a nasogastric output of 8 L daily and respirations of 10 bpm has the following - laboratory values:

This clinical information is most consistent with which of the following?

A) Compensated metabolic alkalosis
B) Uncompensated respiratory alkalosis
C) Uncompensated metabolic alkalosis
D) Compensated respiratory alkalosis

4. A patient presents to the emergency department with a generalized rash. When questioned about recent changes in medication therapy, the patient reports starting glyburide 2 week ago.
Which of the following may be used to assess the causality between glyburide use and the patient's rash?

A) CAGE Questionnaire
B) Modified Morisky Scale
C) Naranjo Algorithm
D) Brief Medication Questionnaire

5. In designing a clinical trial, the method utilized to deal with inherent differences between groups is to:

A) Use a control or comparison group.
B) Use blinding techniques.
C) Evaluate the results using statistical methods.
D) Assign patients to groups randomly.

Solutions: